PUBLICATIONS

The following is a list of publications demonstrating the activity of I-con1™. The actual publications can also be obtained on-line at the following link:http://www.yale.edu/ocr/garen.html. This link also contains a copy of a published PCT directed to the I-con1™ technology.

Tongalp H. Tezel, Ewa Bodek, Kenan Sonmez, Sankar Kaliappan, Henry J. Kaplan, Zhiwei Hu, and Alan Garen.  Targeting Tissue Factor for Immunotherapy of Choroidal Neovascularization by Intravitreal Delivery of Factor VII-Fc Chimeric Antibody.  Ocular Immunology and Inflammation 2007 15:3-10.
Puran S. Bora, Zhiwei Hu, Tongalp H. Tezel, Jeong-Hyeon Sohn, Shin Goo Kang, Jose M. C. Cruz, Nalini S. Bora, Alan Garen , and Henry J. Kaplan. Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proceedings of the National Academy of Sciences 2003 100: 2679-2684.

Zhiwei Hu and Alan Garen. Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proceedings of the National Academy of Sciences 2001 98: 12180-12185.

Zhiwei Hu and Alan Garen. Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proceedings of the National Academy of Sciences 2000 97: 9221-9225.

Zhiwei Hu, Ying Sun, and Alan Garen. Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proceedings of the National Academy of Sciences 1999 96: 8161-8166.